AlphaFold predicted structure
PDYN · P01213
Mean pLDDT
58.7/ 100
Low
254 residues
Confidence breakdown
- Very high(≥ 90)2%
- Confident(70–90)20%
- Low(50–70)43%
- Very low(< 50)35%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
PDYN
Chr 20p13prodynorphin
- Aliases:
- PENKB, ADCA
- MANE:
- ENST00000217305.3
Annotations refreshed 10 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Ataxia and cerebellar anomalies - narrow panel
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownHereditary ataxia
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownHereditary neuropathy or pain disorder
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedChildhood onset dystonia, chorea or related movement disorder
Hereditary neuropathy
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedAdult onset neurodegenerative disorder
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownHereditary ataxia with onset in adulthood
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownIntellectual disability
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Disease associations (Open Targets)
spinocerebellar ataxia type 23
0.79rectosigmoid junction neoplasm
0.29neurodegenerative disease
0.26hereditary disease
0.19thrombocytopenia 4
0.14hemorrhagic disease
0.13Anxiety
0.10polycystic ovary syndrome
0.08alcohol dependence
0.07alcohol drinking
0.07
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Proenkephalin-B
Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity)