AlphaFold predicted structure
PEX13 · Q92968
Mean pLDDT
64.9/ 100
Low
403 residues
Confidence breakdown
- Very high(≥ 90)17%
- Confident(70–90)29%
- Low(50–70)20%
- Very low(< 50)35%
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AlphaFold (Jumper et al., 2021) · CC BY 4.0
PEX13
Chr 2p15peroxisomal biogenesis factor 13
- MANE:
- ENST00000295030.6
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Adult onset leukodystrophy
BIALLELIC, autosomal or pseudoautosomalArthrogryposis
BIALLELIC, autosomal or pseudoautosomalBilateral congenital or childhood onset cataracts
BIALLELIC, autosomal or pseudoautosomalDDG2P
BIALLELIC, autosomal or pseudoautosomalFetal anomalies
BIALLELIC, autosomal or pseudoautosomalFetal hydrops
BIALLELIC, autosomal or pseudoautosomalInherited white matter disorders
BIALLELIC, autosomal or pseudoautosomalIntellectual disability
BIALLELIC, autosomal or pseudoautosomal
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Disease associations (Open Targets)
Zellweger syndrome
0.81peroxisome biogenesis disorder 11A (Zellweger)
0.79peroxisome biogenesis disorder 11B
0.77Zellweger spectrum disorders
0.69peroxisome biogenesis disorder
0.69peroxisomal disease
0.62Peroxisome biogenesis disorder-Zellweger syndrome spectrum
0.62neurodegenerative disease
0.48lysosomal storage disease
0.40peroxisome biogenesis disorder 2B
0.37
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Peroxisomal membrane protein PEX13
Component of the PEX13-PEX14 docking complex, a translocon channel that specifically mediates the import of peroxisomal cargo proteins bound to PEX5 receptor (PubMed:28765278, PubMed:8858165, PubMed:9653144). The PEX13-PEX14 docking complex forms a large import pore which can be opened to a diameter of about 9 nm (By similarity). Mechanistically, PEX5 receptor along with cargo proteins associates with the PEX14 subunit of the PEX13-PEX14 docking complex in the cytosol, leading to the insertion of the receptor into the organelle membrane with the concomitant translocation of the cargo into the peroxisome matrix (PubMed:28765278, PubMed:8858165, PubMed:9653144). Involved in the import of PTS1- and PTS2-type containing proteins (PubMed:8858165, PubMed:9653144)