PIGW

Chr 17q12

phosphatidylinositol glycan anchor biosynthesis class W

Aliases:: Gwt1, FLJ37433, PIG-W
MANE:: ENST00000614443.2

OMIM: 610275 ↗NCBI: 284098 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

PIGW · Q7Z7B1

v62025-08-01

Predicted Aligned Error matrix for PIGW — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

87.5/ 100

Confident

504 residues

Confidence breakdown

Very high(≥ 90)63%
Confident(70–90)29%
Low(50–70)3%
Very low(< 50)5%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Congenital disorders of glycosylation
BIALLELIC, autosomal or pseudoautosomal
Early onset or syndromic epilepsy
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal
Likely inborn error of metabolism
BIALLELIC, autosomal or pseudoautosomal
DDG2P
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

hyperphosphatasia-intellectual disability syndrome
0.65
hereditary disease
0.42
hypercoagulability syndrome due to glycosylphosphatidylinositol deficiency
0.40
Global developmental delay
0.27
Abnormal skeletal morphology
0.27
cleft palate
0.27
schizophrenia
0.06
anorexia nervosa
0.05
attention deficit-hyperactivity disorder
0.05
type 2 diabetes mellitus
0.04

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Glucosaminyl-phosphatidylinositol-acyltransferase PIGW

Acyltransferase that catalyzes the acyl transfer from an acyl-CoA at the 2-OH position of the inositol ring of a 6-(alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol (glucosaminyl phosphatidylinositol, GlcN-PI) to generate a 2-acyl-6-alpha-D-glucosaminyl-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol (glucosaminyl acyl phosphatidylinositol, GlcN-(acyl)PI) and participates in the fourth step of GPI-anchor biosynthesis (By similarity). Required for the transport of GPI-anchored proteins to the plasma membrane (PubMed:24367057). Acylation during GPI-anchor biosynthesis is not essential for the subsequent mannosylation and is usually removed soon after the attachment of GPIs to proteins (By similarity)