PIGY

Chr 4q22.1

phosphatidylinositol glycan anchor biosynthesis class Y

Aliases:: MGC14156, PIG-Y
MANE:: ENST00000527353.2

OMIM: 610662 ↗NCBI: 84992 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

PIGY · Q3MUY2

v62025-08-01

Predicted Aligned Error matrix for PIGY — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

89.5/ 100

Confident

71 residues

Confidence breakdown

Very high(≥ 90)61%
Confident(70–90)37%
Low(50–70)3%
Very low(< 50)0%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

neurodegenerative disease
0.55
hyperphosphatasia-intellectual disability syndrome
0.53
hypercoagulability syndrome due to glycosylphosphatidylinositol deficiency
0.51
lysosomal storage disease
0.37
mitochondrial disease
0.33
chronic obstructive pulmonary disease
0.03
response to bronchodilator
0.03
malunion fracture
0.03
colorectal cancer
0.02
ulcerative colitis
0.02

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y

Part of the glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex that catalyzes the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol and participates in the first step of GPI biosynthesis (PubMed:16162815). May act by regulating the catalytic subunit PIGA (PubMed:16162815)