PLAGL1

Chr 6q24.2

PLAG1 like zinc finger 1

Aliases:: ZAC, LOT1
MANE:: ENST00000674357.1

OMIM: 603044 ↗NCBI: 5325 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

PLAGL1 · Q9UM63

v62025-08-01

Predicted Aligned Error matrix for PLAGL1 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

56.6/ 100

Low

463 residues

Confidence breakdown

Very high(≥ 90)0%
Confident(70–90)36%
Low(50–70)12%
Very low(< 50)52%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Multi locus imprinting disorders
MONOALLELIC, autosomal or pseudoautosomal, maternally imprinted (paternal allele expressed)

Disease associations (Open Targets)

transient neonatal diabetes mellitus
0.48
neurodegenerative disease
0.35
adult onset asthma
0.29
alcohol drinking
0.27
stroke disorder
0.27
protozoa infectious disease
0.26
radiation injury
0.25
myoepithelial tumor
0.11
neoplasm
0.10
glioblastoma
0.08

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Zinc finger protein PLAGL1

Acts as a transcriptional activator (PubMed:9722527). Involved in the transcriptional regulation of type 1 receptor for pituitary adenylate cyclase-activating polypeptide