PLAT

Chr 8p11.21

plasminogen activator, tissue type

MANE:: ENST00000220809.9

OMIM: 173370 ↗NCBI: 5327 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

PLAT · P00750

v62025-08-01

Predicted Aligned Error matrix for PLAT — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

80.9/ 100

Confident

562 residues

Confidence breakdown

Very high(≥ 90)35%
Confident(70–90)48%
Low(50–70)7%
Very low(< 50)10%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Inherited bleeding disorders
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal
Thrombophilia with a likely monogenic cause
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

pulmonary embolism
0.61
myocardial infarction
0.59
hemorrhage
0.59
acute myocardial infarction
0.57
stroke disorder
0.51
Recurrent thrombophlebitis
0.50
heart failure
0.47
ST Elevation Myocardial Infarction
0.46
ischemic stroke
0.45
Stroke
0.43

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Tissue-type plasminogen activator

Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. During oocyte activation, plays a role in cortical granule reaction in the zona reaction, which contributes to the block to polyspermy (By similarity)