AlphaFold predicted structure
PLOD2 · O00469
Mean pLDDT
92.3/ 100
Very high
737 residues
Confidence breakdown
- Very high(≥ 90)87%
- Confident(70–90)7%
- Low(50–70)2%
- Very low(< 50)4%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
PLOD2
Chr 3q24procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
- Aliases:
- LH2, TLH
- MANE:
- ENST00000282903.10
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Arthrogryposis
BIALLELIC, autosomal or pseudoautosomalDDG2P
BIALLELIC, autosomal or pseudoautosomalFetal anomalies
BIALLELIC, autosomal or pseudoautosomalOsteogenesis imperfecta
BIALLELIC, autosomal or pseudoautosomalSkeletal dysplasia
BIALLELIC, autosomal or pseudoautosomalIntellectual disability
BIALLELIC, autosomal or pseudoautosomal
Disease associations (Open Targets)
Bruck syndrome
0.78osteogenesis imperfecta
0.57osteoarthritis, hip
0.52osteoarthritis
0.50osteoarthritis, knee
0.45Abnormality of the skeletal system
0.42skeletal dysplasia
0.37clubfoot
0.34Bowing of the long bones
0.33cleft palate
0.33
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2
Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links
Diseases associated with PLOD2
Curated MONDO disease pages that list PLOD2 among their top associated genes.