AlphaFold predicted structure
PODXL · O00592
Mean pLDDT
52.9/ 100
Low
558 residues
Confidence breakdown
- Very high(≥ 90)5%
- Confident(70–90)18%
- Low(50–70)17%
- Very low(< 50)60%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
PODXL
Chr 7q32.3podocalyxin like
- Aliases:
- PCLP, Gp200, PC, PODXL1, PDX
- MANE:
- ENST00000378555.8
Annotations refreshed 9 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Proteinuric renal disease
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Disease associations (Open Targets)
hypertensive disorder
0.46Young adult-onset Parkinsonism
0.44cardiovascular disorder
0.40young-onset Parkinson disease
0.40familial nephrotic syndrome
0.37atypical juvenile parkinsonism
0.37Increased blood pressure
0.35schizophrenia
0.32kidney disorder
0.31Blindness
0.30
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Podocalyxin
Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells