AlphaFold predicted structure
POLE2 · P56282
Mean pLDDT
93.0/ 100
Very high
527 residues
Confidence breakdown
- Very high(≥ 90)81%
- Confident(70–90)15%
- Low(50–70)3%
- Very low(< 50)1%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
POLE2
Chr 14q21.3DNA polymerase epsilon 2, accessory subunit
- Aliases:
- DPE2
- MANE:
- ENST00000216367.10
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
COVID-19 research
BIALLELIC, autosomal or pseudoautosomalPrimary immunodeficiency or monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomal
Disease associations (Open Targets)
acute lymphoblastic leukemia
0.60non-small cell lung carcinoma
0.60B-cell chronic lymphocytic leukemia
0.59acute myeloid leukemia
0.59exocrine pancreatic carcinoma
0.58ovarian carcinoma
0.56neoplasm
0.55breast cancer
0.53breast carcinoma
0.53myelodysplastic syndrome
0.52
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
DNA polymerase epsilon subunit 2
Accessory component of the DNA polymerase epsilon complex (PubMed:10801849). Participates in DNA repair and in chromosomal DNA replication (By similarity)
Diseases associated with POLE2
Curated MONDO disease pages that list POLE2 among their top associated genes.