AlphaFold predicted structure
POLR2C · P19387
Mean pLDDT
92.1/ 100
Very high
275 residues
Confidence breakdown
- Very high(≥ 90)85%
- Confident(70–90)8%
- Low(50–70)5%
- Very low(< 50)2%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
POLR2C
Chr 16q21RNA polymerase II subunit C
- Aliases:
- RPB3
- MANE:
- ENST00000219252.10
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Moderate Evidence (Amber)
Primary ovarian insufficiency
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedCongenital hypothyroidism
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedCytopenia - NOT Fanconi anaemia
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedCytopenias and congenital anaemias
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Disease associations (Open Targets)
HIV infectious disease
0.60influenza
0.37acrocephalosyndactyly
0.37dengue disease
0.37genetic non-acquired premature ovarian failure
0.32coronary atherosclerosis
0.32neurodegenerative disease
0.26primary ovarian failure
0.18Premature ovarian insufficiency
0.18deafness
0.11
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
DNA-directed RNA polymerase II subunit RPB3
Core component of RNA polymerase II (Pol II), a DNA-dependent RNA polymerase which synthesizes mRNA precursors and many functional non-coding RNAs using the four ribonucleoside triphosphates as substrates
Diseases associated with POLR2C
Curated MONDO disease pages that list POLR2C among their top associated genes.