popeye domain cAMP effector 2
Annotations refreshed 9 hours ago.
Moderate Evidence (Amber)
Paediatric or syndromic cardiomyopathy
BIALLELIC, autosomal or pseudoautosomalProgressive cardiac conduction disease
BIALLELIC, autosomal or pseudoautosomalRomano-Ward syndrome
familial long QT syndrome
hypertrophic cardiomyopathy
Rare familial disorder with hypertrophic cardiomyopathy
familial isolated dilated cardiomyopathy
left ventricular noncompaction
familial atrial fibrillation
Familial short QT syndrome
atrial septal defect
arrhythmogenic right ventricular dysplasia 1
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Popeye domain-containing protein 2
Important for the maintenance of cardiac function (PubMed:40409267). Plays a regulatory function in heart rate dynamics mediated, at least in part, through cAMP-binding and, probably, by increasing cell surface expression of the potassium channel KCNK2 and enhancing current density (PubMed:40409267)
POPDC2 · Q9HBU9
Mean pLDDT
75.1/ 100
Confident
364 residues
Confidence breakdown
AlphaFold (Jumper et al., 2021) · CC BY 4.0
