POU3F2

Chr 6q16.1

POU class 3 homeobox 2

Aliases:: POUF3, BRN2, OCT7
MANE:: ENST00000328345.8

OMIM: 600494 ↗NCBI: 5454 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

POU3F2 · P20265

v62025-08-01

Predicted Aligned Error matrix for POU3F2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

60.9/ 100

Low

443 residues

Confidence breakdown

Very high(≥ 90)23%
Confident(70–90)14%
Low(50–70)13%
Very low(< 50)50%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Intellectual disability
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Disease associations (Open Targets)

neurodegenerative disease
0.55
intelligence
0.44
mathematical ability
0.44
attention deficit-hyperactivity disorder
0.38
autism spectrum disorder
0.32
Helicobacter pylori infectious disease
0.32
erectile dysfunction
0.27
alcohol drinking
0.26
arthropathy
0.24
substance abuse
0.22

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

POU domain, class 3, transcription factor 2

Transcription factor that plays a key role in neuronal differentiation (By similarity). Binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a non-conserved spacer region of 0, 2, or 3 nucleotides (By similarity). Acts as a transcriptional activator when binding cooperatively with SOX4, SOX11, or SOX12 to gene promoters (By similarity). The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro (By similarity). Acts downstream of ASCL1, accessing chromatin that has been opened by ASCL1, and promotes transcription of neuronal genes (By similarity)