AlphaFold predicted structure
POU4F3 · Q15319
Mean pLDDT
64.8/ 100
Low
338 residues
Confidence breakdown
- Very high(≥ 90)32%
- Confident(70–90)8%
- Low(50–70)17%
- Very low(< 50)43%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
POU4F3
Chr 5q32POU class 4 homeobox 3
- Aliases:
- BRN3C
- MANE:
- ENST00000646991.2
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Monogenic hearing loss
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedFamilial Meniere Disease
Disease associations (Open Targets)
autosomal dominant nonsyndromic hearing loss
0.71neurodegenerative disease
0.53deafness
0.45Non-syndromic genetic deafness
0.39nonsyndromic genetic hearing loss
0.37Hearing impairment
0.32hearing loss, autosomal recessive
0.29Rare genetic deafness
0.28injury
0.23hereditary disease
0.19
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
POU domain, class 4, transcription factor 3
Acts as a transcriptional activator (PubMed:18228599). Acts by binding to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes (PubMed:18228599). Involved in the auditory system development, required for terminal differentiation of hair cells in the inner ear (By similarity)
Diseases associated with POU4F3
Curated MONDO disease pages that list POU4F3 among their top associated genes.