PPIB

Chr 15q22.31

peptidylprolyl isomerase B

Aliases:: CYPB, OI9, PPIase, B, CYP-S1
MANE:: ENST00000300026.4

OMIM: 123841 ↗NCBI: 5479 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

PPIB · P23284

v62025-08-01

Predicted Aligned Error matrix for PPIB — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

91.8/ 100

Very high

216 residues

Confidence breakdown

Very high(≥ 90)82%
Confident(70–90)1%
Low(50–70)16%
Very low(< 50)1%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Osteogenesis imperfecta
BIALLELIC, autosomal or pseudoautosomal
Skeletal dysplasia
BIALLELIC, autosomal or pseudoautosomal
Optic neuropathy
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Disease associations (Open Targets)

osteogenesis imperfecta type 9
0.66
osteogenesis imperfecta
0.52
osteogenesis imperfecta type 4
0.38
osteogenesis imperfecta type 3
0.38
osteogenesis imperfecta type 2
0.38
skeletal dysplasia
0.37
severe acute respiratory syndrome
0.37
osteogenesis imperfecta, recessive
0.37
diabetic ketoacidosis
0.25
hereditary disease
0.19

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Peptidyl-prolyl cis-trans isomerase B

Peptidyl-prolyl cis-trans isomerase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding