PPP1R21

Chr 2p16.3

protein phosphatase 1 regulatory subunit 21

Aliases:: FLJ16566, Fy-2, FERRY2
MANE:: ENST00000294952.13

OMIM: 618159 ↗NCBI: 129285 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

PPP1R21 · Q6ZMI0

v62025-08-01

Predicted Aligned Error matrix for PPP1R21 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

83.3/ 100

Confident

780 residues

Confidence breakdown

Very high(≥ 90)56%
Confident(70–90)27%
Low(50–70)6%
Very low(< 50)11%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

neurodevelopmental disorder with hypotonia, facial dysmorphism, and brain abnormalities
0.77
neurodegenerative disease
0.50
hereditary disease
0.42
neurodevelopmental disorder
0.37
colorectal cancer
0.29
neurodevelopmental disorder with hypotonia and seizures
0.27
diabetes mellitus
0.25
type 2 diabetes mellitus
0.25
mathematical ability
0.24
handedness
0.19

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Protein phosphatase 1 regulatory subunit 21

Component of the FERRY complex (Five-subunit Endosomal Rab5 and RNA/ribosome intermediary) (PubMed:37267905, PubMed:37267906). The FERRY complex directly interacts with mRNAs and RAB5A, and functions as a RAB5A effector involved in the localization and the distribution of specific mRNAs most likely by mediating their endosomal transport. The complex recruits mRNAs and ribosomes to early endosomes through direct mRNA-interaction (PubMed:37267905). In the complex, PPP1R21 serves as a binding hub connecting all five complex subunits and mediating the binding to mRNA and early endosomes via RAB5A (PubMed:37267906). Putative regulator of protein phosphatase 1 (PP1) activity (PubMed:19389623). May play a role in the endosomal sorting process or in endosome maturation pathway (Probable) (PubMed:30520571)