PPP2R2B

Chr 5q32

protein phosphatase 2 regulatory subunit Bbeta

Aliases:: PR55-BETA, PR52B, B55beta
MANE:: ENST00000394411.9

OMIM: 604325 ↗NCBI: 5521 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

PPP2R2B · Q00005

v62025-08-01

Predicted Aligned Error matrix for PPP2R2B — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

90.5/ 100

Very high

443 residues

Confidence breakdown

Very high(≥ 90)78%
Confident(70–90)13%
Low(50–70)4%
Very low(< 50)4%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Early onset or syndromic epilepsy
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Intellectual disability
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Adult onset dystonia, chorea or related movement disorder
Other
Adult onset neurodegenerative disorder
Other
Ataxia and cerebellar anomalies - narrow panel
Other
Childhood onset dystonia, chorea or related movement disorder
Other
DDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Hereditary ataxia
Other

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Disease associations (Open Targets)

neurodegenerative disease
0.50
spinocerebellar ataxia type 12
0.48
schizophrenia
0.36
rheumatic disorder
0.33
placental abruption
0.30
sialadenitis
0.30
premature birth
0.30
jaw disease
0.29
digestive system neoplasm
0.29
dermatophytosis
0.27

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment. Within the PP2A holoenzyme complex, isoform 2 is required to promote proapoptotic activity (By similarity). Isoform 2 regulates neuronal survival through the mitochondrial fission and fusion balance (By similarity)