PPP2R3C

Chr 14q13.2

protein phosphatase 2 regulatory subunit B''gamma

Aliases:: FLJ20644, G4-1, G5PR
MANE:: ENST00000261475.10

OMIM: 615902 ↗NCBI: 55012 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

PPP2R3C · Q969Q6

v62025-08-01

Predicted Aligned Error matrix for PPP2R3C — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

89.9/ 100

Confident

453 residues

Confidence breakdown

Very high(≥ 90)73%
Confident(70–90)18%
Low(50–70)6%
Very low(< 50)2%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

gonadal dysgenesis, dysmorphic facies, retinal dystrophy, and myopathy
0.70
neurodegenerative disease
0.51
Gonadal dysgenesis, XY type - associated anomalies
0.37
XY type gonadal dysgenesis-associated anomalies syndrome
0.37
male infertility due to globozoospermia
0.37
atopic eczema
0.29
Eczematoid dermatitis
0.24
premature birth
0.24
dermatitis
0.21
Abnormality of the skeletal system
0.20

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma

May regulate MCM3AP phosphorylation through phosphatase recruitment (By similarity). May act as a negative regulator of ABCB1 expression and function through the dephosphorylation of ABCB1 by TFPI2/PPP2R3C complex (PubMed:24333728). May play a role in the activation-induced cell death of B-cells (By similarity)