PPP2R5C

Chr 14q32.31

protein phosphatase 2 regulatory subunit B'gamma

Aliases:: B56G, PR61G, B56gamma
MANE:: ENST00000694906.1

OMIM: 601645 ↗NCBI: 5527 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

PPP2R5C · Q13362

v62025-08-01

Predicted Aligned Error matrix for PPP2R5C — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

84.4/ 100

Confident

524 residues

Confidence breakdown

Very high(≥ 90)69%
Confident(70–90)11%
Low(50–70)6%
Very low(< 50)14%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Early onset or syndromic epilepsy
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Intellectual disability
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Disease associations (Open Targets)

Houge-Janssens syndrome 4
0.53
cancer
0.53
neurodegenerative disease
0.48
complex neurodevelopmental disorder
0.42
chronic myelogenous leukemia, BCR-ABL1 positive
0.39
vertebral column disorder
0.29
Intellectual disability
0.27
restless legs syndrome
0.24
Alzheimer disease
0.24
transient ischemic attack
0.23

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and might also direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage-induced inhibition of cell proliferation. PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation