PRDM15

Chr 21q22.3

PR/SET domain 15

MANE:: ENST00000398548.6

OMIM: 617692 ↗NCBI: 63977 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

PRDM15 · P57071

v62025-08-01

Predicted Aligned Error matrix for PRDM15 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

56.0/ 100

Low

1,141 residues

Confidence breakdown

Very high(≥ 90)0%
Confident(70–90)36%
Low(50–70)20%
Very low(< 50)44%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Proteinuric renal disease
BIALLELIC, autosomal or pseudoautosomal
Unexplained young onset end-stage renal disease - additional genes
BIALLELIC, autosomal or pseudoautosomal
DDG2P
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

steroid-resistant nephrotic syndrome
0.46
dementia
0.29
Parkinson disease
0.29
pervasive developmental disorder
0.27
Rare pervasive developmental disorder
0.27
type 2 diabetes mellitus
0.26
insomnia
0.22
fungal infectious disease
0.17
cholangiocarcinoma
0.07
lymphoma
0.07

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

PR domain zinc finger protein 15

Sequence-specific DNA-binding transcriptional regulator. Plays a role as a molecular node in a transcriptional network regulating embryonic development and cell fate decision. Stimulates the expression of upstream key transcriptional activators and repressors of the Wnt/beta-catenin and MAPK/ERK pathways, respectively, that are essential for naive pluripotency and self-renewal maintenance of embryonic stem cells (ESCs). Specifically promotes SPRY1 and RSPO1 transcription activation through recognition and direct binding of a specific DNA sequence in their promoter regions. Involved in early embryo development (By similarity). Also plays a role in induced pluripotent stem cells (iPSCs) reprogramming (PubMed:28740264)