PRDX3

Chr 10q26.11

peroxiredoxin 3

Aliases:: MER5, AOP-1, SP-22
MANE:: ENST00000298510.4

OMIM: 604769 ↗NCBI: 10935 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

PRDX3 · P30048

v62025-08-01

Predicted Aligned Error matrix for PRDX3 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

84.8/ 100

Confident

256 residues

Confidence breakdown

Very high(≥ 90)75%
Confident(70–90)2%
Low(50–70)4%
Very low(< 50)20%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Ataxia and cerebellar anomalies - narrow panel
BIALLELIC, autosomal or pseudoautosomal
DDG2P
BIALLELIC, autosomal or pseudoautosomal
Hereditary ataxia with onset in adulthood
BIALLELIC, autosomal or pseudoautosomal
Corneal dystrophy
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Disease associations (Open Targets)

spinocerebellar ataxia, autosomal recessive 32
0.65
corneal dystrophy, punctiform and polychromatic pre-descemet
0.57
autosomal recessive cerebellar ataxia
0.27
neurodegenerative disease
0.26
hereditary disease
0.19
cerebellar ataxia
0.19
aceruloplasminemia
0.19
Hepatic fibrosis
0.09
breast cancer
0.09
ovarian carcinoma
0.09

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Thioredoxin-dependent peroxide reductase, mitochondrial

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides (PubMed:17707404, PubMed:29438714, PubMed:33889951, PubMed:7733872). Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol (PubMed:12492477). Required for the maintenance of physical strength (By similarity)