PRKG2

Chr 4q21.21

protein kinase cGMP-dependent 2

Aliases:: cGKII, PRKGR2, PKG2
MANE:: ENST00000264399.6

OMIM: 601591 ↗NCBI: 5593 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

PRKG2 · Q13237

v62025-08-01

Predicted Aligned Error matrix for PRKG2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

82.0/ 100

Confident

762 residues

Confidence breakdown

Very high(≥ 90)50%
Confident(70–90)32%
Low(50–70)6%
Very low(< 50)11%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
BIALLELIC, autosomal or pseudoautosomal
Skeletal dysplasia
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

acromesomelic dysplasia
0.67
spondylometaphyseal dysplasia, pagnamenta type
0.55
Abnormality of the skeletal system
0.48
atrial fibrillation
0.41
dengue disease
0.37
osteoarthritis, hip
0.37
alcohol drinking
0.33
smoking behavior
0.31
adolescent idiopathic scoliosis
0.29
insomnia
0.29

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

cGMP-dependent protein kinase 2

Crucial regulator of intestinal secretion and bone growth. Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum (PubMed:33106379). Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863 (By similarity). Acts as a regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2 in mechanically stimulated osteoblasts. Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1/FRA1, FOSL2/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation (By similarity)