PROC

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

• Inherited bleeding disorders

  BOTH monoallelic and biallelic, autosomal or pseudoautosomal

• Thrombophilia with a likely monogenic cause

  BOTH monoallelic and biallelic, autosomal or pseudoautosomal

• Fetal anomalies

  BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

• hereditary thrombophilia due to congenital protein C deficiency

  0.85

• venous thromboembolism

  0.74

• deep vein thrombosis

  0.71

• thrombophilia due to protein C deficiency, autosomal dominant

  0.70

• protein c deficiency

  0.69

• thrombophilia due to protein C deficiency, autosomal recessive

  0.69

• phlebitis

  0.65

• Thrombophlebitis

  0.65

• Abnormal thrombosis

  0.63

• thrombophilia

  0.60

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Diseases associated with PROC

Curated MONDO disease pages that list PROC among their top associated genes.

• venous thromboembolismRare