PROK1

Chr 1p13.3

prokineticin 1

Aliases:: PK1, PRK1, EGVEGF, EG-VEGF
MANE:: ENST00000271331.4

OMIM: 606233 ↗NCBI: 84432 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

PROK1 · P58294

v62025-08-01

Predicted Aligned Error matrix for PROK1 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

90.0/ 100

Very high

105 residues

Confidence breakdown

Very high(≥ 90)74%
Confident(70–90)19%
Low(50–70)7%
Very low(< 50)0%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Paediatric pseudo-obstruction syndrome
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Non-syndromic familial congenital anorectal malformations

Disease associations (Open Targets)

Hirschsprung disease
0.37
Hypercholesterolemia
0.28
colorectal cancer
0.10
neoplasm
0.09
cancer
0.08
posterior cortical atrophy
0.08
infection
0.08
metabolic syndrome
0.07
polycystic ovary syndrome
0.06
intestinal impaction
0.06

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Prokineticin-1

Potently contracts gastrointestinal (GI) smooth muscle. Induces proliferation, migration and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. Has little or no effect on a variety of other endothelial and non-endothelial cell types. Induces proliferation and differentiation, but not migration, of enteric neural crest cells. Directly influences neuroblastoma progression by promoting the proliferation and migration of neuroblastoma cells. Positively regulates PTGS2 expression and prostaglandin synthesis. May play a role in placentation. May play a role in normal and pathological testis angiogenesis