PROK2

Chr 3p13

prokineticin 2

Aliases:: PK2, BV8, MIT1, KAL4
MANE:: ENST00000295619.4

OMIM: 607002 ↗NCBI: 60675 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

PROK2 · Q9HC23

v62025-08-01

Predicted Aligned Error matrix for PROK2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

70.1/ 100

Confident

129 residues

Confidence breakdown

Very high(≥ 90)5%
Confident(70–90)47%
Low(50–70)40%
Very low(< 50)9%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Hypogonadotropic hypogonadism
BIALLELIC, autosomal or pseudoautosomal
Hypogonadotropic hypogonadism (GMS)
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BOTH monoallelic and biallelic, autosomal or pseudoautosomal

Disease associations (Open Targets)

hypogonadotropic hypogonadism
0.73
hypogonadotropic hypogonadism 4 with or without anosmia
0.69
Kallmann syndrome
0.50
hereditary disease
0.45
male infertility with azoospermia or oligozoospermia due to single gene mutation
0.34
Male infertility with spermatogenesis disorder
0.33
Alzheimer disease
0.29
smoking initiation
0.27
malignant renal pelvis neoplasm
0.22
dermatophytosis
0.21

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Prokineticin-2

May function as an output molecule from the suprachiasmatic nucleus (SCN) that transmits behavioral circadian rhythm. May also function locally within the SCN to synchronize output. Potently contracts gastrointestinal (GI) smooth muscle