PROKR1

Chr 2p13.3

prokineticin receptor 1

Aliases:: PKR1, ZAQ, GPR73a
MANE:: ENST00000303786.5

OMIM: 607122 ↗NCBI: 10887 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

PROKR1 · Q8TCW9

v62025-08-01

Predicted Aligned Error matrix for PROKR1 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

77.3/ 100

Confident

393 residues

Confidence breakdown

Very high(≥ 90)46%
Confident(70–90)27%
Low(50–70)8%
Very low(< 50)19%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Paediatric pseudo-obstruction syndrome
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Disease associations (Open Targets)

Hirschsprung disease
0.44
Aganglionic megacolon
0.26
retinitis pigmentosa
0.12
Progressive cone dystrophy
0.11
Cone rod dystrophy
0.09
Oguchi disease
0.08
Familial drusen
0.08
neoplasm
0.08
adult-onset foveomacular vitelliform dystrophy
0.08
Familial exudative vitreoretinopathy
0.08

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Prokineticin receptor 1

Receptor for prokineticin 1. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase. May play a role during early pregnancy