AlphaFold predicted structure
PROS1 · P07225
Mean pLDDT
82.9/ 100
Confident
676 residues
Confidence breakdown
- Very high(≥ 90)43%
- Confident(70–90)42%
- Low(50–70)8%
- Very low(< 50)7%
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AlphaFold (Jumper et al., 2021) · CC BY 4.0
PROS1
Chr 3q11.1protein S
- MANE:
- ENST00000394236.9
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Inherited bleeding disorders
BOTH monoallelic and biallelic, autosomal or pseudoautosomalThrombophilia with a likely monogenic cause
BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Disease associations (Open Targets)
thrombophilia due to protein S deficiency, autosomal dominant
0.82hereditary thrombophilia due to congenital protein S deficiency
0.75protein S deficiency
0.70thrombophilia due to protein S deficiency, autosomal recessive
0.69venous thromboembolism
0.68pulmonary embolism
0.66deep vein thrombosis
0.61Thromboembolism
0.57heart disorder
0.52dengue disease
0.51
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Vitamin K-dependent protein S
Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis
Diseases associated with PROS1
Curated MONDO disease pages that list PROS1 among their top associated genes.