PROZ

Chr 13q34

protein Z, vitamin K dependent plasma glycoprotein

Aliases:: PZ
MANE:: ENST00000375547.7

OMIM: 176895 ↗NCBI: 8858 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

PROZ · P22891

v62025-08-01

Predicted Aligned Error matrix for PROZ — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

85.1/ 100

Confident

400 residues

Confidence breakdown

Very high(≥ 90)60%
Confident(70–90)22%
Low(50–70)13%
Very low(< 50)6%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Thrombophilia with a likely monogenic cause
BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Inherited bleeding disorders

Disease associations (Open Targets)

protein Z deficiency
0.28
injury
0.26
Thromboembolism
0.22
Abnormal bleeding
0.11
Thrombocytopenia
0.11
hepatocellular carcinoma
0.09
glioma
0.06
central nervous system cancer
0.06
tuberculosis
0.06
Venous thrombosis
0.04

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Vitamin K-dependent protein Z

Appears to assist hemostasis by binding thrombin and promoting its association with phospholipid vesicles. Inhibits activity of the coagulation protease factor Xa in the presence of SERPINA10, calcium and phospholipids