PRPF3

Chr 1q21.2

pre-mRNA processing factor 3

Aliases:: Prp3, hPrp3, SNRNP90
MANE:: ENST00000324862.7

OMIM: 607301 ↗NCBI: 9129 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

PRPF3 · O43395

v62025-08-01

Predicted Aligned Error matrix for PRPF3 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

73.3/ 100

Confident

683 residues

Confidence breakdown

Very high(≥ 90)24%
Confident(70–90)40%
Low(50–70)17%
Very low(< 50)20%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Retinal disorders
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Glaucoma (developmental)
Structural eye disease
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

retinitis pigmentosa
0.76
Retinal dystrophy
0.50
autosomal dominant retinitis pigmentosa
0.37
eye disorder
0.37
neurodegenerative disease
0.35
Headache
0.26
smoking initiation
0.25
Abnormality of the skeletal system
0.22
osteoarthritis
0.20
Hip pain
0.20

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

U4/U6 small nuclear ribonucleoprotein Prp3

Plays a role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex)