PRSS1

Chr 7q34

serine protease 1

MANE:: ENST00000311737.12

OMIM: 276000 ↗NCBI: 5644 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

PRSS1 · P07477

v62025-08-01

Predicted Aligned Error matrix for PRSS1 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

92.1/ 100

Very high

247 residues

Confidence breakdown

Very high(≥ 90)85%
Confident(70–90)6%
Low(50–70)5%
Very low(< 50)5%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Pancreatitis
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Inherited pancreatic cancer
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
COVID-19 research
Unknown

Disease associations (Open Targets)

hereditary chronic pancreatitis
0.81
chronic pancreatitis
0.73
trypsinogen deficiency
0.37
Hypocalcemic vitamin D-resistant rickets
0.35
acute pancreatitis
0.34
autoimmune disorder of central nervous system
0.34
pancreatitis
0.29
neurodegenerative disease
0.27
alcoholic pancreatitis
0.20
malignant pancreatic neoplasm
0.18

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Serine protease 1

Has activity against the synthetic substrates Boc-Phe-Ser-Arg-Mec, Boc-Leu-Thr-Arg-Mec, Boc-Gln-Ala-Arg-Mec and Boc-Val-Pro-Arg-Mec. The single-chain form is more active than the two-chain form against all of these substrates