PSMG2

Chr 18p11.21

proteasome assembly chaperone 2

Aliases:: HCCA3, MDS003, MGC15092, CLAST3, HsT1707
MANE:: ENST00000317615.11

OMIM: 609702 ↗NCBI: 56984 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

PSMG2 · Q969U7

v62025-08-01

Predicted Aligned Error matrix for PSMG2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

92.5/ 100

Very high

264 residues

Confidence breakdown

Very high(≥ 90)80%
Confident(70–90)16%
Low(50–70)3%
Very low(< 50)1%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

COVID-19 research
BIALLELIC, autosomal or pseudoautosomal
Primary immunodeficiency or monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

proteasome-associated autoinflammatory syndrome 4
0.51
Joubert syndrome 1
0.48
retinitis pigmentosa
0.36
Bardet-Biedl syndrome 1
0.33
Short stature
0.30
hypothyroidism
0.13
inflammatory bowel disease
0.12
type 1 diabetes mellitus
0.12
Crohn disease
0.11
myxedema
0.10

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Proteasome assembly chaperone 2

Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization