PTCRA

Chr 6p21.1

pre T cell antigen receptor alpha

Aliases:: PTA, PT-ALPHA
MANE:: ENST00000304672.6

OMIM: 606817 ↗NCBI: 171558 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

PTCRA · Q6ISU1

v62025-08-01

Predicted Aligned Error matrix for PTCRA — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

63.8/ 100

Low

281 residues

Confidence breakdown

Very high(≥ 90)20%
Confident(70–90)23%
Low(50–70)14%
Very low(< 50)43%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Primary immunodeficiency or monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

immunodeficiency 126, susceptibility to
0.49
Autoimmunity
0.37
lymphopenia
0.37
neurodegenerative disease
0.27
smoking initiation
0.17
injury
0.10
acute lymphoblastic leukemia
0.08
substance abuse
0.03
attention deficit-hyperactivity disorder
0.03
central nervous system cancer
0.02

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Pre T-cell antigen receptor alpha

Component of the pre-T-cell receptor complex (composed of PTCRA, TCRB and the CD3 complex) that has a crucial role in early T-cell development, particularly alpha-beta T cell differentiation