PTPN13

Chr 4q21.3

protein tyrosine phosphatase non-receptor type 13

Aliases:: PTP1E, PTP-BAS, PTPL1, PTP-BL
MANE:: ENST00000411767.7

OMIM: 600267 ↗NCBI: 5783 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

PTPN13 · Q12923

v62025-08-01

Predicted Aligned Error matrix for PTPN13 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

60.0/ 100

Low

2,485 residues

Confidence breakdown

Very high(≥ 90)20%
Confident(70–90)28%
Low(50–70)6%
Very low(< 50)46%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Haematological malignancies cancer susceptibility
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

pancreatic ductal adenocarcinoma
0.37
gastric carcinoma
0.37
endometrial endometrioid adenocarcinoma
0.37
ovarian endometrioid adenocarcinoma with squamous differentiation
0.37
kidney neoplasm
0.37
Transitional Meningioma
0.37
skin basal cell carcinoma
0.37
hemangioblastoma
0.37
carcinoma of liver and intrahepatic biliary tract
0.37
Atypical Meningioma
0.37

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Tyrosine-protein phosphatase non-receptor type 13

Tyrosine phosphatase which negatively regulates FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling (PubMed:15611135). May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2 (PubMed:23604317)