protein tyrosine phosphatase receptor type C
Annotations refreshed 9 hours ago.
Diagnostic Grade (Green)
COVID-19 research
BIALLELIC, autosomal or pseudoautosomalPrimary immunodeficiency or monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomalimmunodeficiency 104
immunodeficiency 105
T-B+ severe combined immunodeficiency due to JAK3 deficiency
T-B+ severe combined immunodeficiency due to CD45 deficiency
asthma
Omenn syndrome
T-B+ severe combined immunodeficiency
T-B- severe combined immunodeficiency
respiratory system disorder
Graves disease
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Receptor-type tyrosine-protein phosphatase C
Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor (PubMed:35767951). Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity). Interacts with CLEC10A at antigen presenting cell-T cell contact; CLEC10A on immature dendritic cells recognizes Tn antigen-carrying PTPRC/CD45 receptor on effector T cells and modulates T cell activation threshold to limit autoreactivity
PTPRC · P08575
Mean pLDDT
76.1/ 100
Confident
1,306 residues
Confidence breakdown
AlphaFold (Jumper et al., 2021) · CC BY 4.0
