PTPRO

Chr 12p12.3

protein tyrosine phosphatase receptor type O

Aliases:: PTPU2, GLEPP1, PTP-U2, PTP-oc, NPHS6
MANE:: ENST00000281171.9

OMIM: 600579 ↗NCBI: 5800 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

PTPRO · Q16827

v62025-08-01

Predicted Aligned Error matrix for PTPRO — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

77.4/ 100

Confident

1,216 residues

Confidence breakdown

Very high(≥ 90)33%
Confident(70–90)42%
Low(50–70)11%
Very low(< 50)15%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Proteinuric renal disease
Unexplained kidney failure in young people

Disease associations (Open Targets)

familial idiopathic steroid-resistant nephrotic syndrome
0.61
neurodegenerative disease
0.42
nephrotic syndrome
0.39
Parkinson disease
0.39
endometriosis
0.38
Alzheimer disease
0.38
multiple sclerosis
0.37
lysosomal storage disease
0.37
hypertensive disorder
0.32
intelligence
0.30

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Receptor-type tyrosine-protein phosphatase U

Tyrosine-protein phosphatase which dephosphorylates CTNNB1. Regulates CTNNB1 function both in cell adhesion and signaling. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity. May play a role in megakaryocytopoiesis

Curated MONDO disease pages that list PTPRO among their top associated genes.

familial idiopathic steroid-resistant nephrotic syndromeRare

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Disease associations (Open Targets)

Protein function (UniProt)

Diseases associated with PTPRO