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PTX3

Chr 3q25.32

pentraxin 3

Aliases:
TSG-14
MANE:
ENST00000295927.4
OMIM: 602492 ↗NCBI: 5806 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

  • COVID-19 research

    Unknown

Disease associations (Open Targets)

  • neoplasm

    0.12

  • Sepsis

    0.12

  • COVID-19

    0.12

  • rheumatoid arthritis

    0.12

  • polycystic ovary syndrome

    0.11

  • breast carcinoma

    0.11

  • infection

    0.11

  • breast cancer

    0.11

  • cancer

    0.11

  • glioblastoma

    0.11

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Pentraxin-related protein PTX3

Plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility

Data sources: HGNC (CC BY 4.0), AlphaFold (CC BY 4.0, Jumper et al. Nature 2021), Genomics England PanelApp (CC BY 4.0), ClinGen, Open Targets (CC0), UniProt.

Not for sole clinical decision-making. Always verify against primary sources.