AlphaFold predicted structure
PVR · P15151
Mean pLDDT
84.9/ 100
Confident
417 residues
Confidence breakdown
- Very high(≥ 90)66%
- Confident(70–90)14%
- Low(50–70)8%
- Very low(< 50)12%
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AlphaFold (Jumper et al., 2021) · CC BY 4.0
PVR
Chr 19q13.31PVR cell adhesion molecule
- Aliases:
- CD155, HVED, Necl-5, NECL5, Tage4
- MANE:
- ENST00000425690.8
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Moderate Evidence (Amber)
COVID-19 research
Unknown
Disease associations (Open Targets)
Alzheimer disease
0.37multiple sclerosis
0.27neurodegenerative disease
0.27liver disorder
0.27polyarteritis nodosa
0.16deep vein thrombosis
0.16neoplasm
0.12hepatocellular carcinoma
0.11cancer
0.11Miyoshi myopathy
0.11
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Poliovirus receptor
Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytotoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration
Diseases associated with PVR
Curated MONDO disease pages that list PVR among their top associated genes.