RABGAP1

Chr 9q33.2-q33.3

RAB GTPase activating protein 1

Aliases:: GAPCenA, TBC1D11
MANE:: ENST00000373647.9

OMIM: 615882 ↗NCBI: 23637 ↗Ensembl ↗

Annotations refreshed 2 months ago.

Predicted protein structure

AlphaFold predicted structure

RABGAP1 · Q9Y3P9

v62025-08-01

Predicted Aligned Error matrix for RABGAP1 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

76.4/ 100

Confident

1,069 residues

Confidence breakdown

Very high(≥ 90)41%
Confident(70–90)33%
Low(50–70)7%
Very low(< 50)19%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

neurodegenerative disease
0.53
diabetes mellitus
0.29
type 2 diabetes mellitus
0.26
lysosomal storage disease
0.25
amyloidosis
0.24
osteoarthritis, knee
0.20
diabetic neuropathy
0.20
cartilage disease
0.19
complex neurodevelopmental disorder
0.18
kidney failure
0.18

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Rab GTPase-activating protein 1

May act as a GTPase-activating protein of RAB6A. May play a role in microtubule nucleation by centrosome. May participate in a RAB6A-mediated pathway involved in the metaphase-anaphase transition