AlphaFold predicted structure
RAC3 · P60763
Mean pLDDT
93.9/ 100
Very high
192 residues
Confidence breakdown
- Very high(≥ 90)87%
- Confident(70–90)7%
- Low(50–70)6%
- Very low(< 50)0%
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AlphaFold (Jumper et al., 2021) · CC BY 4.0
RAC3
Chr 17q25.3Rac family small GTPase 3
- MANE:
- ENST00000306897.9
Annotations refreshed 10 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
DDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownEarly onset or syndromic epilepsy
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownFetal anomalies
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedIntellectual disability
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownMalformations of cortical development
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Disease associations (Open Targets)
neurodevelopmental disorder with structural brain anomalies and dysmorphic facies
0.74Intellectual disability
0.42Abnormal brain morphology
0.42complex neurodevelopmental disorder
0.37Distal shortening of limbs
0.27hereditary disease
0.19lung adenocarcinoma
0.10hepatocellular carcinoma
0.10neoplasm
0.10breast cancer
0.10
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Ras-related C3 botulinum toxin substrate 3
Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles. Promotes cell adhesion and spreading on fibrinogen in a CIB1 and alpha-IIb/beta3 integrin-mediated manner