AlphaFold predicted structure
RALGAPA1 · Q6GYQ0
Mean pLDDT
69.4/ 100
Low
2,036 residues
Confidence breakdown
- Very high(≥ 90)29%
- Confident(70–90)35%
- Low(50–70)7%
- Very low(< 50)29%
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AlphaFold (Jumper et al., 2021) · CC BY 4.0
RALGAPA1
Chr 14q13.2Ral GTPase activating protein catalytic subunit alpha 1
- Aliases:
- GRIPE, DKFZp667F074, KIAA0884, Tulip1, RalGAPalpha1
- MANE:
- ENST00000680220.1
Annotations refreshed 9 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
DDG2P
BIALLELIC, autosomal or pseudoautosomalEarly onset or syndromic epilepsy
BIALLELIC, autosomal or pseudoautosomalFetal anomalies
BIALLELIC, autosomal or pseudoautosomalIntellectual disability
BIALLELIC, autosomal or pseudoautosomal
Disease associations (Open Targets)
neurodevelopmental disorder with hypotonia, neonatal respiratory insufficiency, and thermodysregulation
0.74neurodegenerative disease
0.50hereditary disease
0.42neurodevelopmental disorder
0.37sleep apnea syndrome
0.34nodular goiter
0.33ovarian neoplasm
0.30ovarian dysfunction
0.29arthropathy
0.29placental retention
0.26
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Ral GTPase-activating protein subunit alpha-1
Catalytic subunit of the heterodimeric RalGAP1 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB