RANBP2

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

• COVID-19 research

  BOTH monoallelic and biallelic, autosomal or pseudoautosomal

• Primary immunodeficiency or monogenic inflammatory bowel disease

  MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

• Early onset or syndromic epilepsy

  MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

• Likely inborn error of metabolism

  MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

• Undiagnosed metabolic disorders

  MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

• Childhood onset dystonia, chorea or related movement disorder

• DDG2P

  MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

• Intellectual disability

  MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

• familial acute necrotizing encephalopathy

  0.70

• HIV infectious disease

  0.55

• influenza

  0.54

• viral infectious disease

  0.54

• neurodegenerative disease

  0.53

• hepatocellular carcinoma

  0.50

• cancer

  0.47

• squamous cell lung carcinoma

  0.42

• inflammatory myofibroblastic tumor

  0.38

• COVID-19

  0.38

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Diseases associated with RANBP2

Curated MONDO disease pages that list RANBP2 among their top associated genes.

• viral infectious diseaseRare