RASGRP1

Chr 15q14

RAS guanyl releasing protein 1

Aliases:: CalDAG-GEFII, RASGRP
MANE:: ENST00000310803.10

OMIM: 603962 ↗NCBI: 10125 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

RASGRP1 · O95267

v62025-08-01

Predicted Aligned Error matrix for RASGRP1 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

71.7/ 100

Confident

797 residues

Confidence breakdown

Very high(≥ 90)34%
Confident(70–90)31%
Low(50–70)6%
Very low(< 50)29%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

COVID-19 research
BIALLELIC, autosomal or pseudoautosomal
Primary immunodeficiency or monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

immunodeficiency 64
0.73
type 2 diabetes mellitus
0.53
rheumatoid arthritis
0.52
hypothyroidism
0.52
diabetes mellitus
0.51
systemic lupus erythematosus
0.50
Immunodeficiency
0.47
immune system disorder
0.47
immunodeficiency disease
0.47
Crohn disease
0.42

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

RAS guanyl-releasing protein 1

Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP (PubMed:15899849, PubMed:23908768, PubMed:27776107, PubMed:29155103). Activates the Erk/MAP kinase cascade (PubMed:15899849). Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras (PubMed:10807788, PubMed:12839994, PubMed:27776107, PubMed:29155103). Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways (PubMed:19933860). Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses. May also function in differentiation of other cell types (PubMed:12845332)