AlphaFold predicted structure
RAX2 · Q96IS3
Mean pLDDT
69.8/ 100
Low
184 residues
Confidence breakdown
- Very high(≥ 90)29%
- Confident(70–90)5%
- Low(50–70)59%
- Very low(< 50)8%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
RAX2
Chr 19p13.3retina and anterior neural fold homeobox 2
- Aliases:
- MGC15631, ARMD6, CORD11
- MANE:
- ENST00000555633.3
Annotations refreshed 9 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Retinal disorders
BOTH monoallelic and biallelic, autosomal or pseudoautosomalGlaucoma (developmental)
Structural eye disease
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Disease associations (Open Targets)
cone-rod dystrophy 11
0.63retinitis pigmentosa 95
0.58Cone rod dystrophy
0.52age-related macular degeneration
0.46cone-rod dystrophy
0.46Rod-cone dystrophy
0.46Retinal dystrophy
0.39retinitis pigmentosa
0.37age related macular degeneration 6
0.19macular degeneration
0.12
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Retina and anterior neural fold homeobox protein 2
May be involved in modulating the expression of photoreceptor specific genes. Binds to the Ret-1 and Bat-1 element within the rhodopsin promoter