AlphaFold predicted structure
RBM10 · P0DW28
Mean pLDDT
51.6/ 100
Low
130 residues
Confidence breakdown
- Very high(≥ 90)0%
- Confident(70–90)5%
- Low(50–70)48%
- Very low(< 50)48%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
RBM10
Chr Xp11.3RNA binding motif protein 10
- Aliases:
- DXS8237E, KIAA0122, GPATC9, ZRANB5, GPATCH9
- MANE:
- ENST00000377604.8
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Clefting
X-LINKED: hemizygous mutation in males, biallelic mutations in femalesDDG2P
X-LINKED: hemizygous mutation in males, biallelic mutations in femalesFetal anomalies
X-LINKED: hemizygous mutation in males, biallelic mutations in femalesIntellectual disability
X-LINKED: hemizygous mutation in males, biallelic mutations in femalesLimb disorders
X-LINKED: hemizygous mutation in males, biallelic mutations in females
Disease associations (Open Targets)
TARP syndrome
0.79lung adenocarcinoma
0.63neurodegenerative disease
0.53pancreatic adenocarcinoma
0.51non-small cell lung carcinoma
0.51colorectal adenocarcinoma
0.51hereditary disease
0.47urinary bladder cancer
0.40bladder transitional cell carcinoma
0.37cleft palate
0.37
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
RNA-binding protein 10
Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3' (PubMed:21256132). May be involved in post-transcriptional processing, most probably in mRNA splicing (PubMed:18315527). Binds to RNA homopolymers, with a preference for poly(G) and poly(U) and little for poly(A) (By similarity). May bind to specific miRNA hairpins (PubMed:28431233)
Diseases associated with RBM10
Curated MONDO disease pages that list RBM10 among their top associated genes.