AlphaFold predicted structure
RDH11 · Q8TC12
Mean pLDDT
91.9/ 100
Very high
318 residues
Confidence breakdown
- Very high(≥ 90)80%
- Confident(70–90)11%
- Low(50–70)9%
- Very low(< 50)0%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
RDH11
Chr 14q24.1retinol dehydrogenase 11
- Aliases:
- MDT1, SDR7C1, ARSDR1
- MANE:
- ENST00000381346.9
Annotations refreshed 9 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Moderate Evidence (Amber)
Bilateral congenital or childhood onset cataracts
BIALLELIC, autosomal or pseudoautosomalIntellectual disability
BIALLELIC, autosomal or pseudoautosomalLimb girdle muscular dystrophies, myofibrillar myopathies and distal myopathies
BIALLELIC, autosomal or pseudoautosomalMalformations of cortical development
BIALLELIC, autosomal or pseudoautosomalRetinal disorders
BIALLELIC, autosomal or pseudoautosomal
Disease associations (Open Targets)
Genetic malformation syndrome with short stature
0.60neurodegenerative disease
0.36Retinal dystrophy
0.34acute tonsillitis
0.28Neurodevelopmental delay
0.27cervical carcinoma
0.24optic atrophy
0.11open-angle glaucoma
0.09myopia
0.09degeneration of macula and posterior pole
0.08
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Retinol dehydrogenase 11
Retinol dehydrogenase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinol, and to a lesser extent on 13-cis-retinol (PubMed:12036956, PubMed:12226107, PubMed:29410696). Exhibits a low reductive activity towards unsaturated medium-chain aldehydes such as cis -6-nonenal and no activity toward nonanal or 4-hydroxy-nonenal (PubMed:15865448). Has no dehydrogenase activity towards steroid (PubMed:12036956, PubMed:12226107)