AlphaFold predicted structure
RDX · P35241
Mean pLDDT
86.6/ 100
Confident
583 residues
Confidence breakdown
- Very high(≥ 90)70%
- Confident(70–90)16%
- Low(50–70)7%
- Very low(< 50)7%
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AlphaFold (Jumper et al., 2021) · CC BY 4.0
RDX
Chr 11q22.3radixin
- MANE:
- ENST00000645495.2
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Monogenic hearing loss
BIALLELIC, autosomal or pseudoautosomal
Disease associations (Open Targets)
hearing loss, autosomal recessive
0.70nonsyndromic genetic hearing loss
0.44deafness
0.38Non-syndromic genetic deafness
0.38hearing loss disorder
0.37Rare genetic deafness
0.34cervical carcinoma
0.32myocardial infarction
0.31abdominal aortic aneurysm
0.29coronary artery disorder
0.24
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Radixin
Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane