RELT

Chr 11q13.4

RELT TNF receptor

Aliases:: FLJ14993
MANE:: ENST00000064780.7

OMIM: 611211 ↗NCBI: 84957 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

RELT · Q969Z4

v62025-08-01

Predicted Aligned Error matrix for RELT — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

62.8/ 100

Low

430 residues

Confidence breakdown

Very high(≥ 90)18%
Confident(70–90)19%
Low(50–70)21%
Very low(< 50)42%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Amelogenesis imperfecta
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

amelogenesis imperfecta
0.52
Hypoplastic amelogenesis imperfecta
0.39
hypocalcified amelogenesis imperfecta
0.37
Pain
0.28
diverticular disease
0.25
pernicious anemia
0.24
Varicose veins
0.20
lymphatic system disorder
0.20
vein disorder
0.20
Crohn disease
0.20

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Tumor necrosis factor receptor superfamily member 19L

May play a role in apoptosis (PubMed:19969290, PubMed:28688764). Induces activation of MAPK14/p38 and MAPK8/JNK MAPK cascades, when overexpressed (PubMed:16530727). Involved in dental enamel formation (PubMed:30506946)