RGS2

Chr 1q31.2

regulator of G protein signaling 2

MANE:: ENST00000235382.7

OMIM: 600861 ↗NCBI: 5997 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

RGS2 · P41220

v62025-08-01

Predicted Aligned Error matrix for RGS2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

80.1/ 100

Confident

211 residues

Confidence breakdown

Very high(≥ 90)60%
Confident(70–90)11%
Low(50–70)10%
Very low(< 50)19%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Bleeding and platelet disorders
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

cataract
0.28
trauma complication
0.27
spondylolisthesis
0.27
neoplasm
0.11
breast cancer
0.11
breast carcinoma
0.10
polyostotic fibrous dysplasia
0.09
gastric cancer
0.09
Alzheimer disease
0.08
Huntington disease
0.08

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Regulator of G protein signaling 2

Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:11063746, PubMed:19478087). It is involved in the negative regulation of the angiotensin-activated signaling pathway (PubMed:28784619). Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity). Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein (PubMed:19736320)