RGS9

Chr 17q24.1

regulator of G protein signaling 9

Aliases:: PERRS, RGS9L, MGC26458, MGC111763
MANE:: ENST00000262406.10

OMIM: 604067 ↗NCBI: 8787 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

RGS9 · O75916

v62025-08-01

Predicted Aligned Error matrix for RGS9 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

73.1/ 100

Confident

674 residues

Confidence breakdown

Very high(≥ 90)57%
Confident(70–90)6%
Low(50–70)4%
Very low(< 50)33%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Retinal disorders
BIALLELIC, autosomal or pseudoautosomal
Glaucoma (developmental)
Structural eye disease
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

bradyopsia
0.65
neurodegenerative disease
0.37
eye disorder
0.37
Retinal dystrophy
0.36
Leber congenital amaurosis
0.35
actinic keratosis
0.28
hereditary disease
0.19
alcohol drinking
0.14
stroke disorder
0.14
Hepatomegaly
0.12

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Regulator of G protein signaling 9

Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to GNAT1. Involved in phototransduction; key element in the recovery phase of visual transduction (By similarity)