AlphaFold predicted structure
RHO · P08100
Mean pLDDT
88.8/ 100
Confident
348 residues
Confidence breakdown
- Very high(≥ 90)68%
- Confident(70–90)22%
- Low(50–70)5%
- Very low(< 50)5%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
RHO
Chr 3q22.1rhodopsin
- Aliases:
- OPN2, CSNBAD1
- MANE:
- ENST00000296271.4
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Retinal disorders
BOTH monoallelic and biallelic, autosomal or pseudoautosomalGlaucoma (developmental)
Structural eye disease
BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Disease associations (Open Targets)
retinitis pigmentosa
0.85congenital stationary night blindness
0.70Retinal dystrophy
0.58fundus albipunctatus
0.53retinitis punctata albescens
0.46retinal disorder
0.44autosomal recessive primary microcephaly
0.37Rod-cone dystrophy
0.36Cone rod dystrophy
0.36Coats disease
0.36
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Rhodopsin
G protein-coupled photoreceptor that activates the G protein transducin (t) signaling pathway in response to light and is essential for image-forming vision under low-light conditions (PubMed:6140680, PubMed:7846071, PubMed:8107847). Required for postnatal photoreceptor cell viability (PubMed:12566452, PubMed:2215617). Activation occurs when the covalently bound 11-cis-retinal chromophore absorbs a photon and isomerizes to all-trans-retinal, inducing a conformational change in the opsin that triggers G protein-mediated phototransduction (Probable) (PubMed:26200343, PubMed:28753425, PubMed:8107847). Signal termination occurs via receptor phosphorylation, which promotes binding of arrestin (SAG) and displacement of the G protein alpha subunit (Probable) (PubMed:26200343)
Diseases associated with RHO
Curated MONDO disease pages that list RHO among their top associated genes.