RHOB

Chr 2p24.1

ras homolog family member B

Aliases:: RHOH6, MST081
MANE:: ENST00000272233.6

OMIM: 165370 ↗NCBI: 388 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

RHOB · P62745

v62025-08-01

Predicted Aligned Error matrix for RHOB — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

92.3/ 100

Very high

196 residues

Confidence breakdown

Very high(≥ 90)88%
Confident(70–90)3%
Low(50–70)2%
Very low(< 50)8%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Childhood onset hereditary spastic paraplegia
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

neurodegenerative disease
0.45
cerebral palsy
0.19
ventral hernia
0.18
Recurrent pancreatitis
0.11
neoplasm
0.10
breast cancer
0.10
breast carcinoma
0.10
nonpapillary renal cell carcinoma
0.09
non-small cell lung carcinoma
0.08
osteosarcoma
0.08

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Rho-related GTP-binding protein RhoB

Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells